The goal of the Pharmacokinetics Laboratory is to contribute to drug therapy through the following basic research.

1. Dynamic analysis of drug pharmacokinetics and the effects/side effects using pathological model animals
   The pharmacokinetics after drug administration can be clarified by measuring plasma concentration, however the expected results are not always proportional to the plasma concentration. Therefore, by quantitatively modeling the transition of the effects from plasma concentration transition, it becomes possible to predict the results of pharmacokinetics changes due to pathology and interactions. We are currently conducting research on therapeutic agents for hypertension, diabetes, and dementia using pathological model animals.
2. Clarifying the relationship between drug solubility and absorbability (membrane penetration)Research on methods for improving the absorbability of poorly water-soluble medicines that do not depend on solubility in water
   Many medicines are poor water-soluble, and solubilization technology has been developed with the goal of improving their absorbability. However, improving solubility is not always necessary for improving medicine absorbability, as the presence of medicine molecules is now considered to be vital. Therefore, our goal is to clarify new absorption mechanisms, such as the relationship between the dispersed state and absorbability of medicine molecules, and the factors that affect that dispersed state.